A HIF-1α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells

A HIF-1α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells

Abstract Background A hypoxic environment often persists within solid tumors, including hepatocellular carcinoma (HCC). Hypoxia-inducible factor-1α (HIF-1α) can accelerate cancer malignancy by inducing hypoxia-dependent expression of various genes. Tumor hypoxia can also induce metabolic reprogrammi...

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Bibliographic Details
Main Authors: Shohei Matsufuji, Yoshihiko Kitajima, Kazuki Higure, Naoya Kimura, Sachiko Maeda, Kohei Yamada, Kotaro Ito, Tomokazu Tanaka, Keita Kai, Hirokazu Noshiro
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Cancer & Metabolism
Subjects:
HCC
HIF-1α
Hypoxia
Fatty acid oxidation
YC-1
Palmitic acids
Online Access:https://doi.org/10.1186/s40170-023-00328-w

Internet

https://doi.org/10.1186/s40170-023-00328-w

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