Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.

Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.

p53 plays a central role in tumor suppression. It does so by inducing anti-proliferative processes as a response to various tumor-promoting stresses. p53 is regulated by the ubiquitin ligase Mdm2. The optimal function of Mdm2 requires Daxx, which stabilizes Mdm2 through the deubiquitinase Hausp/USP7...

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Bibliographic Details
Main Authors: Jun Tang, Trisha Agrawal, Qian Cheng, Like Qu, Michael D Brewer, Jiandong Chen, Xiaolu Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566025?pdf=render

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http://europepmc.org/articles/PMC3566025?pdf=render

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