Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

Microglia controls the immune system response in the brain. Specifically, the activation and dysregulation of the NLRP3 inflammasome is responsible for the initiation of the inflammatory process through IL-1β and IL-18 release. In this work, we have focused on studying the effect of melatonin on the...

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Bibliographic Details
Main Authors: Víctor Farré-Alins, Paloma Narros-Fernández, Alejandra Palomino-Antolín, Céline Decouty-Pérez, Ana Belen Lopez-Rodriguez, Esther Parada, Alicia Muñoz-Montero, Vanessa Gómez-Rangel, Francisco López-Muñoz, Eva Ramos, Águeda González-Rodríguez, Luis Gandía, Alejandro Romero, Javier Egea
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Antioxidants
Subjects:
melatonin
inflammasome
α7 nicotinic receptor
autophagy
Online Access:https://www.mdpi.com/2076-3921/9/12/1299

Internet

https://www.mdpi.com/2076-3921/9/12/1299

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