Deciphering the Intercellular Communication Between Immune Cells and Altered Vascular Smooth Muscle Cell Phenotypes in Aortic Aneurysm From Single-Cell Transcriptome Data

Deciphering the Intercellular Communication Between Immune Cells and Altered Vascular Smooth Muscle Cell Phenotypes in Aortic Aneurysm From Single-Cell Transcriptome Data

BackgroundVascular smooth muscle cell (VSMC) phenotype switching has been preliminarily found in aortic aneurysms. However, two major questions were raised: (1) What factors drive phenotypic switching of VSMCs in aortic aneurysms? (2) What role does VSMC phenotype transformation play in aortic aneur...

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Bibliographic Details
Main Authors: Genmao Cao, Zhengchao Lu, Ruiyuan Gu, Xuezhen Xuan, Ruijing Zhang, Jie Hu, Honglin Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
aortic aneurysm
immune cells
VSMC phenotype switching
intercellular communication
single-cell transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.936287/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.936287/full

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