Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1

Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1

Abstract Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium channel. Pregabalin, used clinically in the treatment of chronic pain and epilepsy, inhibits P/Q-type calcium channel activity and recent studies su...

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Bibliographic Details
Main Authors: Stuart M. Cain, Sascha R. A. Alles, Ray Gopaul, Louis-Philippe Bernier, Andrew C. Yung, Andrew Bauman, Yi Yang, Glen B. Baker, Piotr Kozlowski, Brian A. MacVicar, Terrance P. Snutch
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Molecular Brain
Subjects:
Spreading depolarization
Pregabalin
Familial hemiplegic migraine
Spontaneous excitatory postsynaptic currents
Online Access:https://doi.org/10.1186/s13041-023-01062-6

Internet

https://doi.org/10.1186/s13041-023-01062-6

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