Synthesis, Docking Studies and Pharmacological Evaluation of Serotoninergic Ligands Containing a 5-Norbornene-2-Carboxamide Nucleus

Synthesis, Docking Studies and Pharmacological Evaluation of Serotoninergic Ligands Containing a 5-Norbornene-2-Carboxamide Nucleus

A new series of 5-norbornene-2-carboxamide derivatives was prepared and their affinities to the 5-HT<sub>1A</sub>, 5-HT<sub>2A</sub>, and 5-HT<sub>2C</sub> receptors were evaluated and compared to a previously synthesized series of derivatives characterized by exo...

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Main Authors:	Rosa Sparaco, Ewa Kędzierska, Agnieszka A. Kaczor, Anna Bielenica, Elisa Magli, Beatrice Severino, Angela Corvino, Ewa Gibuła-Tarłowska, Jolanta H. Kotlińska, Giorgia Andreozzi, Paolo Luciano, Elisa Perissutti, Francesco Frecentese, Marcello Casertano, Anna Leśniak, Magdalena Bujalska-Zadrożny, Małgorzata Oziębło, Raffaele Capasso, Vincenzo Santagada, Giuseppe Caliendo, Ferdinando Fiorino
Format:	Article
Language:	English
Published:	MDPI AG 2022-10-01
Series:	Molecules
Subjects:	5-norbornene-2-carboxilic acid serotonin arylpiperazine derivatives 5-HT<sub>1A</sub> 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptor ligands
Online Access:	https://www.mdpi.com/1420-3049/27/19/6492

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