Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model

Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model

RAS GTPases are ubiquitous GDP/GTP-binding proteins that function as molecular switches in cellular signalling and control numerous signalling pathways and biological processes. Pathogenic mutations in RAS genes severely affect cellular homeostasis, leading to cancer when occurring in somatic cells...

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Bibliographic Details
Main Authors: Sayantan Nandi, Saravanakkumar Chennappan, Yannik Andrasch, Miray Fidan, Melanie Engler, Mubashir Ahmad, Jan P. Tuckermann, Martin Zenker, Ion Cristian Cirstea
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
RASopathy
HRAS
Costello syndrome
osteoporosis
osteoclast
osteoclastogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1000575/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.1000575/full

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