Preclinical Evaluation of <sup>99m</sup>Tc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Preclinical Evaluation of <sup>99m</sup>Tc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

Radionuclide imaging of HER2 expression in tumours may enable stratification of patients with breast, ovarian, and gastroesophageal cancers for HER2-targeting therapies. A first-generation HER2-binding affibody molecule [<sup>99m</sup>Tc]Tc-ZHER2:V2 demonstrated favorable imaging propert...

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Bibliographic Details
Main Authors: Maryam Oroujeni, Sara S. Rinne, Anzhelika Vorobyeva, Annika Loftenius, Joachim Feldwisch, Per Jonasson, Vladimir Chernov, Anna Orlova, Fredrik Y. Frejd, Vladimir Tolmachev
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
HER2
radionuclide molecular imaging
affibody molecule
technetium-99m
second-generation scaffold
Online Access:https://www.mdpi.com/1422-0067/22/5/2770

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https://www.mdpi.com/1422-0067/22/5/2770

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