HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function

HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function

Abstract Background Peripheral nerve injury can cause neuroinflammation and neuromodulation that lead to mitochondrial dysfunction and neuronal apoptosis in the dorsal root ganglion (DRG) and spinal cord, contributing to neuropathic pain and motor dysfunction. Hyperbaric oxygen therapy (HBOT) has be...

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Bibliographic Details
Main Authors: Yaseen Awad-Igbaria, Nadine Ferreira, Ali Keadan, Reem Sakas, Doron Edelman, Alon Shamir, Jean Francous-Soustiel, Eilam Palzur
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Translational Medicine
Subjects:
Neuropathic pain
Neuroinflammation
Neuromodulation
Apoptosis
Mitochondrial respiration
Hyperbaric oxygen therapy (HBOT)
Online Access:https://doi.org/10.1186/s12967-023-04414-x

Internet

https://doi.org/10.1186/s12967-023-04414-x

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