Expression of TAM-R in Human Immune Cells and Unique Regulatory Function of MerTK in IL-10 Production by Tolerogenic DC

Expression of TAM-R in Human Immune Cells and Unique Regulatory Function of MerTK in IL-10 Production by Tolerogenic DC

Tumor-infiltrating myeloid cells are a key component of the immune infiltrate often correlated with a poor prognosis due to their capacities to sustain an immunosuppressive environment. Among membrane receptors implicated in myeloid cell functions, Tyro3, Axl, and MerTK, which are a family of tyrosi...

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Bibliographic Details
Main Authors: Paul Giroud, Sarah Renaudineau, Laura Gudefin, Alexandre Calcei, Thierry Menguy, Caroline Rozan, Jacques Mizrahi, Christophe Caux, Vanessa Duong, Jenny Valladeau-Guilemond
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
MerTK
dendritic cells
macrophages
tumor immunity
immunosuppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.564133/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.564133/full

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