Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants

Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants

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We recently published a preliminary assessment of the activity of a poly (ADP-ribose) polymerase (PARP) inhibitor, stenoparib, also known as 2X-121, which inhibits viral replication by affecting pathways of the host. Here we show that stenoparib effectively inhibits a SARS-CoV-2 wild type (BavPat1/2...

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Bibliographic Details
Main Authors: Katherine E. Zarn, Sierra A. Jaramillo, Anthony R. Zapata, Nathan E. Stone, Ashley N. Jones, Haley E. Nunnally, Erik W. Settles, Ken Ng, Paul S. Keim, Steen Knudsen, Patricia M. Nuijten, Aloys S. L. Tijsma, Christopher T. French
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473406/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473406/?tool=EBI

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