Development of glycyrrhetinic acid ligand-functionalized liposomes for targeting hepatocellular carcinoma: Synthesis, preparation, characterization, and evaluation

Development of glycyrrhetinic acid ligand-functionalized liposomes for targeting hepatocellular carcinoma: Synthesis, preparation, characterization, and evaluation

In this study, we successfully synthesized a novel glycyrrhetinic acid (GA) derivate compound as a liposomal carrier. Glycyrrhetinic acid-diaminododecane-cholesterol (GA-DA-CH) was synthesized from GA, diaminododecane, and cholesteryl hemisuccinate by two-step amidation under catalytic conditions. T...

Full description

Bibliographic Details
Main Authors: Yuan Lin, Yimin Zhang, Zhuang Xiong, Min Wu, Muling Zeng, Chuangnan Li, Fujin Liu, Yazhi Liao, Chunping Liu, Jing Chen
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Arabian Journal of Chemistry
Subjects:
Ligand synthesis
GA-DA-CH
Liposomal preparation
Physicochemical characterization
Hepatocellular-targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223005932

Internet

http://www.sciencedirect.com/science/article/pii/S1878535223005932

Similar Items