Interferon-lambda 3 and 4 Polymorphisms Increase Sustained Virological Responses and Regulate Innate Immunity in Antiviral Therapy With Pegylated Interferon-Alpha

Interferon-lambda 3 and 4 Polymorphisms Increase Sustained Virological Responses and Regulate Innate Immunity in Antiviral Therapy With Pegylated Interferon-Alpha

Sustained virologic response (SVR) in chronic hepatitis C (CHC) treatment denotes that the host genetics controls the immune response and unequivocally contribute to viral clearance or disease severity. In this context, single nucleotide polymorphisms (SNPs) in the locus of interferon lambda 3 and 4...

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Main Authors: Andréa Marques Vieira da Silva, Lucia Elena Alvarado-Arnez, Tamiris Azamor, Leonardo Ribeiro Batista-Silva, Thyago Leal-Calvo, Ohanna Cavalcanti de Lima Bezerra, Marcelo Ribeiro-Alves, Fernanda de Souza Gomes Kehdy, Patrícia Cristina da Costa Neves, Camilla Bayma, Jane da Silva, Alessandro Fonseca de Souza, Marcelo Muller, Elisabete Ferreira de Andrade, Ana Carolina Magalhães Andrade, Eliane Matos dos Santos, Janaína Reis Xavier, Maria De Lourdes De Sousa Maia, Rolando Páez Meireles, Hugo Nodarse Cuni, Guilherme Becker Sander, Paulo Dornelles Picon, Denise C S Matos, Milton Ozório Moraes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Interferon lambda 3 e 4
hepatitis C
pegylated interferon
sustained virologic response
immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.656393/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.656393/full

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