Transcriptomic analysis provides a new insight: Oleuropein reverses high glucose-induced osteogenic inhibition in bone marrow mesenchymal stem cells via Wnt10b activation

Transcriptomic analysis provides a new insight: Oleuropein reverses high glucose-induced osteogenic inhibition in bone marrow mesenchymal stem cells via Wnt10b activation

Adverse events of diabetes mellitus (DM) include bone damages, such as the increased incidence of osteoporosis and bone fractures, which are known as diabetic osteopathy. The pathogenic mechanism of diabetic osteopathy is complex, and hyperglycemia is a vital cause involved in it. Bone marrow mesenc...

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Bibliographic Details
Main Authors: An Lao, Yu Chen, Yiting Sun, Tiange Wang, Kaili Lin, Jiaqiang Liu, Jianyong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
transcriptome sequencing
BMSCs
high glucose microenvironment
Wnt10b
oleuropein
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.990507/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.990507/full

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