A Principal Component Informed Approach to Address Polygenic Risk Score Transferability Across European Cohorts

A Principal Component Informed Approach to Address Polygenic Risk Score Transferability Across European Cohorts

One important confounder in genome-wide association studies (GWASs) is population genetic structure, which may generate spurious associations if not properly accounted for. This may ultimately result in a biased polygenic risk score (PRS) prediction, especially when applied to another population. To...

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Bibliographic Details
Main Authors: Katri Pärna, Ilja M. Nolte, Harold Snieder, Krista Fischer, Estonian Biobank Research Team, Davide Marnetto, Luca Pagani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Genetics
Subjects:
genome-wide association study
population structure
principal component analysis
polygenic risk score
transferability
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.899523/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.899523/full

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