Osmotic diuresis by SGLT2 inhibition stimulates vasopressin‐induced water reabsorption to maintain body fluid volume

Osmotic diuresis by SGLT2 inhibition stimulates vasopressin‐induced water reabsorption to maintain body fluid volume

Abstract Most of the filtered glucose is reabsorbed in the early proximal tubule by the sodium‐glucose cotransporter SGLT2. The glycosuric effect of the SGLT2 inhibitor ipragliflozin is linked to a diuretic and natriuretic effect that activates compensatory increases in fluid and food intake to stab...

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Bibliographic Details
Main Authors: Takahiro Masuda, Shigeaki Muto, Keiko Fukuda, Minami Watanabe, Ken Ohara, Hermann Koepsell, Volker Vallon, Daisuke Nagata
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Physiological Reports
Subjects:
bioimpedance analysis
glucosuria
SGLT2 inhibition
vasopressin
water reabsorption
Online Access:https://doi.org/10.14814/phy2.14360

Internet

https://doi.org/10.14814/phy2.14360

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