Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast

Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast

ABSTRACT The inositol pyrophosphate signaling molecule 1,5-IP8 is an agonist of RNA 3'-processing and transcription termination in fission yeast that regulates the expression of phosphate acquisition genes pho1, pho84, and tgp1. IP8 is synthesized from 5-IP7 by the Asp1 N-terminal kinase domain...

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Bibliographic Details
Main Authors: Lauren Bednor, Ana M. Sanchez, Angad Garg, Stewart Shuman, Beate Schwer
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
inositol pyrophosphate
fission yeast
glycerophosphocholine transporter
phosphate homeostasis
Online Access:https://journals.asm.org/doi/10.1128/mbio.03062-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03062-23

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