Toxin B Variants from <i>Clostridium difficile</i> Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors

Toxin B Variants from <i>Clostridium difficile</i> Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors

<i>Clostridium difficile</i> induces antibiotic-associated diarrhea due to the release of toxin A (TcdA) and toxin B (TcdB), the latter being its main virulence factor. The epidemic strain NAP1/027 has an increased virulence attributed to different factors. We compared cellular intoxicat...

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Bibliographic Details
Main Authors: Diana López-Ureña, Josué Orozco-Aguilar, Yendry Chaves-Madrigal, Andrea Ramírez-Mata, Amanda Villalobos-Jimenez, Stefan Ost, Carlos Quesada-Gómez, César Rodríguez, Panagiotis Papatheodorou, Esteban Chaves-Olarte
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Toxins
Subjects:
<i>Clostridium difficile</i>
NAP1/027 toxin B
receptor binding
frizzled receptors
Online Access:https://www.mdpi.com/2072-6651/11/6/348

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https://www.mdpi.com/2072-6651/11/6/348

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