Novel p53 therapies for head and neck cancer

Inactivation of the tumor suppressor p53 is the predominant pathogenetic event in head and neck squamous cell carcinoma (HNSCC). The p53 pathway in HNSCC can be compromised through multiple mechanisms including gene mutations, hyperactivation of endogenous negative p53 regulators and by the human pa...

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Bibliographic Details
Main Authors: Mario R. Castellanos, Quintin Pan
Format: Article
Language:English
Published: Wiley 2016-06-01
Series:World Journal of Otorhinolaryngology-Head and Neck Surgery
Online Access:http://www.sciencedirect.com/science/article/pii/S2095881116300142