Novel p53 therapies for head and neck cancer

Inactivation of the tumor suppressor p53 is the predominant pathogenetic event in head and neck squamous cell carcinoma (HNSCC). The p53 pathway in HNSCC can be compromised through multiple mechanisms including gene mutations, hyperactivation of endogenous negative p53 regulators and by the human pa...

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Detalles Bibliográficos
Main Authors: Mario R. Castellanos, Quintin Pan
Formato: Artigo
Idioma:English
Publicado: Wiley 2016-06-01
Series:World Journal of Otorhinolaryngology-Head and Neck Surgery
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2095881116300142