The Curcumin Analogs 2-Pyridyl Cyclohexanone Induce Apoptosis via Inhibition of the JAK2–STAT3 Pathway in Human Esophageal Squamous Cell Carcinoma Cells

The Curcumin Analogs 2-Pyridyl Cyclohexanone Induce Apoptosis via Inhibition of the JAK2–STAT3 Pathway in Human Esophageal Squamous Cell Carcinoma Cells

Multiple modifications to the structure of curcumin have been investigated with an aim to improve its potency and biochemical properties. Previously, we have synthesized a series of curcumin analogs. In the present study, the anticancer effect of 2-pyridyl cyclohexanone, one of the curcumin analogs,...

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Bibliographic Details
Main Authors: Ying Wang, Pengjun Zhou, Shurong Qin, Dandan Xu, Yukun Liu, Wuyu Fu, Bibo Ruan, Li Zhang, Yi Zhang, Xiao Wang, Yuwei Pan, Sheng Wang, Haizhao Yan, Jinhong Qin, Xiaoyan Wang, Qiuying Liu, Zhiyun Du, Zhong Liu, Yifei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
2-pyridyl cyclohexanone
STAT3
Bcl-2
human esophageal squamous cell carcinoma
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00820/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00820/full

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