An area under the concentration–time curve threshold as a predictor of efficacy and nephrotoxicity for individualizing polymyxin B dosing in patients with carbapenem-resistant gram-negative bacteria

An area under the concentration–time curve threshold as a predictor of efficacy and nephrotoxicity for individualizing polymyxin B dosing in patients with carbapenem-resistant gram-negative bacteria

Abstract Background Evidence supports therapeutic drug monitoring of polymyxin B, but clinical data for establishing an area under the concentration–time curve across 24 h at steady state (AUCss,24 h) threshold are still limited. This study aimed to examine exposure–response/toxicity relationship fo...

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Bibliographic Details
Main Authors: Jing Yang, Shaohua Liu, Jingli Lu, Tongwen Sun, Peile Wang, Xiaojian Zhang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Critical Care
Subjects:
Polymyxin B
AUCss,24 h threshold
Nephrotoxicity
Efficacy
Therapeutic drug monitoring
Online Access:https://doi.org/10.1186/s13054-022-04195-7

Internet

https://doi.org/10.1186/s13054-022-04195-7

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