In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine – A Radioligand for Imaging σ1 Receptors With Positron Emission Tomography (PET)

In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine – A Radioligand for Imaging σ1 Receptors With Positron Emission Tomography (PET)

(S)-[18F]fluspidine ((S)-[18F]1) has recently been explored for positron emission tomography (PET) imaging of sigma-1 receptors in humans. In the current report, we have used plasma samples of healthy volunteers to investigate the radiometabolites of (S)-[18F]1 and elucidate their structures with LC...

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Bibliographic Details
Main Authors: Friedrich-Alexander Ludwig, Steffen Fischer, Richard Houska, Alexander Hoepping, Winnie Deuther-Conrad, Dirk Schepmann, Marianne Patt, Philipp M. Meyer, Swen Hesse, Georg-Alexander Becker, Franziska Ruth Zientek, Jörg Steinbach, Bernhard Wünsch, Osama Sabri, Peter Brust
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
sigma-1 receptors
fluspidine
positron emission tomography
radiometabolites
liquid chromatography-mass spectrometry
liver microsomes
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00534/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00534/full

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