Quantitative structure-activity relationship and molecular docking studies of a series of quinazolinonyl analogues as inhibitors of gamma amino butyric acid aminotransferase

Quantitative structure-activity relationship and molecular docking studies of a series of quinazolinonyl analogues as inhibitors of gamma amino butyric acid aminotransferase

Quantitative structure-activity relationship and molecular docking studies were carried out on a series of quinazolinonyl analogues as anticonvulsant inhibitors. Density Functional Theory (DFT) quantum chemical calculation method was used to find the optimized geometry of the anticonvulsants inhibit...

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Bibliographic Details
Main Authors: Usman Abdulfatai, Adamu Uzairu, Sani Uba
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Advanced Research
Subjects:
QSAR method
Gamma aminobutyric acid aminotransferase
Molecular docking
Density functional theory
Anticonvulsant
Genetic function algorithm
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123216300790

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http://www.sciencedirect.com/science/article/pii/S2090123216300790

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