Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro

Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro

We report the in vitro efficacy of ion-channel inhibitors amantadine, memantine and rimantadine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In VeroE6 cells, rimantadine was most potent followed by memantine and amantadine (50% effective concentrations: 36, 80 and 116 µM, re...

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Bibliographic Details
Main Authors: Yuyong Zhou, Karen A. Gammeltoft, Andrea Galli, Anna Offersgaard, Ulrik Fahnøe, Santseharay Ramirez, Jens Bukh, Judith M. Gottwein
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
drug repurposing
ion-channel inhibitor
antiviral
hepatitis C virus p7 inhibitor
Online Access:https://www.mdpi.com/1999-4915/13/10/2082

Internet

https://www.mdpi.com/1999-4915/13/10/2082

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