Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion

Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion

Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved. Here, we systematically analyze the core genes of the circadian clock (CLOCK, ARNTL, ARNTL2, NPAS2, NR1D1, NR1D2, CRY1, CRY2, RORA, RORB, RO...

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Bibliographic Details
Main Authors: Yingcheng Wu, Baorui Tao, Tianyang Zhang, Yihui Fan, Renfang Mao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
circadian clock
CLOCK
BMAL1
PD-L1
immune evasion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02451/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02451/full

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