The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

Abstract Background The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates. Methods To identify in vivo-relevant BACE1 substrates...

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Bibliographic Details
Main Authors: Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Molecular Neurodegeneration
Subjects:
IL-6 receptor subunit beta
Secretase
IL-6R
Shedding
Trans-signaling
VCAM1
Online Access:https://doi.org/10.1186/s13024-023-00596-6

Internet

https://doi.org/10.1186/s13024-023-00596-6

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