The rare malformation holoprosencephaly: pathogenesis, association with pregestational diabetes and the possible link with food pollutants

Background. Holoprosencephaly is a rare (1/16,000 livebirths) and severe brain malformation occurring during early embryogenesis. The malformation originates from absent or incomplete forebrain division and is associated with altered embryonic patterning. Objectives. A narrative review to identify a...

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Bibliographic Details
Main Authors: Domenica Taruscio, Alberto Mantovani
Format: Article
Language:English
Published: Istituto Superiore di Sanità 2023-12-01
Series:Annali dell'Istituto Superiore di Sanità
Online Access:https://annali.iss.it/index.php/anna/article/view/1619