Tracing the substrate translocation mechanism in P-glycoprotein

Tracing the substrate translocation mechanism in P-glycoprotein

P-glycoprotein (Pgp) is a prototypical ATP-binding cassette (ABC) transporter of great biological and clinical significance.Pgp confers cancer multidrug resistance and mediates the bioavailability and pharmacokinetics of many drugs (Juliano and Ling, 1976; Ueda et al., 1986; Sharom, 2011). Decades o...

Full description

Bibliographic Details
Main Authors: Theresa Gewering, Deepali Waghray, Kristian Parey, Hendrik Jung, Nghi NB Tran, Joel Zapata, Pengyi Zhao, Hao Chen, Dovile Januliene, Gerhard Hummer, Ina Urbatsch, Arne Moeller, Qinghai Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
ABC transporter
P-glycoprotein
mechanism
substrate translocation
covalent ligand
cryo-EM structure
Online Access:https://elifesciences.org/articles/90174

Internet

https://elifesciences.org/articles/90174

Similar Items