Impaired HMG-CoA Reductase Activity Caused by Genetic Variants or Statin Exposure: Impact on Human Adipose Tissue, β-Cells and Metabolome

Impaired HMG-CoA Reductase Activity Caused by Genetic Variants or Statin Exposure: Impact on Human Adipose Tissue, β-Cells and Metabolome

Inhibition of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase is associated with an increased risk of new-onset type 2 diabetes. We studied the association of genetic or pharmacological HMG-CoA reductase inhibition with plasma and adipose tissue (AT) metabolome and AT metabolic pathways. We also...

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Bibliographic Details
Main Authors: Assel Sarsenbayeva, Bipasha Nandi Jui, Giovanni Fanni, Pedro Barbosa, Fozia Ahmed, Robin Kristófi, Jing Cen, Azazul Chowdhury, Stanko Skrtic, Peter Bergsten, Tove Fall, Jan W. Eriksson, Maria J. Pereira
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Metabolites
Subjects:
statins
adipose tissue
β-cell
insulin resistance
glucose uptake
type 2 diabetes
Online Access:https://www.mdpi.com/2218-1989/11/9/574

Internet

https://www.mdpi.com/2218-1989/11/9/574

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