Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

During transcription elongation, RNA polymerase has been assumed to attain equilibrium between pre- and post-translocated states rapidly relative to the subsequent catalysis. Under this assumption, recent single-molecule studies proposed a branched Brownian ratchet mechanism that necessitates a puta...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Manchuta Dangkulwanich, Toyotaka Ishibashi, Shixin Liu, Maria L Kireeva, Lucyna Lubkowska, Mikhail Kashlev, Carlos J Bustamante
Format: Artykuł
Język:English
Wydane: eLife Sciences Publications Ltd 2013-09-01
Seria:eLife
Hasła przedmiotowe:
RNA polymerase II
transcription elongation
Brownian ratchet
translocation
backtracking
optical tweezer
Dostęp online:https://elifesciences.org/articles/00971

Internet

https://elifesciences.org/articles/00971

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