STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses

STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses

DNA vaccines elicit antibody, T helper cell responses and CD8+ T cell responses. Currently, little is known about the mechanism that DNA vaccines employ to induce adaptive immune responses. Prior studies have demonstrated that stimulator of interferon genes (STING) and conventional dendritic cells (...

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Bibliographic Details
Main Authors: Justin Theophilus Ulrich-Lewis, Kevin E. Draves, Kelsey Roe, Megan A. O’Connor, Edward A. Clark, Deborah Heydenburg Fuller
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
DNA vaccine
STING
dendritic cells
type I interferon
cGAS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.861710/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.861710/full

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