Single Nucleotide Polymorphism Induces Divergent Dynamic Patterns in CYP3A5: A Microsecond Scale Biomolecular Simulation of Variants Identified in Sub-Saharan African Populations

Single Nucleotide Polymorphism Induces Divergent Dynamic Patterns in CYP3A5: A Microsecond Scale Biomolecular Simulation of Variants Identified in Sub-Saharan African Populations

Pharmacogenomics aims to reveal variants associated with drug response phenotypes. Genes whose roles involve the absorption, distribution, metabolism, and excretion of drugs, are highly polymorphic between populations. High coverage whole genome sequencing showed that a large proportion of the varia...

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Bibliographic Details
Main Authors: Houcemeddine Othman, Jorge E. B. da Rocha, Scott Hazelhurst
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
pharmacogenomics
molecular dynamics
CYP3A5
sub-Saharan Africa
Online Access:https://www.mdpi.com/1422-0067/22/15/7786

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https://www.mdpi.com/1422-0067/22/15/7786

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