Dolutegravir potentiates platelet activation by a calcium-dependent, ionophore-like mechanism

Dolutegravir potentiates platelet activation by a calcium-dependent, ionophore-like mechanism

Dolutegravir is a highly potent HIV integrase strand transfer inhibitor that is recommended for first-line anti-retroviral treatment in all major treatment guidelines. A recent study has shown that people taking this class of anti-retroviral treatment have a substantially higher risk of early-onset...

Full description

Bibliographic Details
Main Authors: Morris Madzime, Annette J. Theron, Ronald Anderson, Gregory R. Tintinger, Helen C. Steel, Pieter W. A. Meyer, Jan G. Nel, Charles Feldman, Theresa M. Rossouw
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Immunotoxicology
Subjects:
Dolutegravir
platelets
calcium fluxes
CD62P
neutrophil: platelet aggregates
Online Access:https://www.tandfonline.com/doi/10.1080/1547691X.2022.2142705

Internet

https://www.tandfonline.com/doi/10.1080/1547691X.2022.2142705

Similar Items