Terminal bridging of siRNA duplex at the ribose 2′ position controls strand bias and target sequence preference

Terminal bridging of siRNA duplex at the ribose 2′ position controls strand bias and target sequence preference

Small interfering RNA (siRNA) and short hairpin RNA (shRNA) are widely used as RNA interference (RNAi) reagents. Recently, truncated shRNAs that trigger RNAi in a Dicer-independent manner have been developed. We generated a novel class of RNAi reagent, designated enforced strand bias (ESB) RNA, in w...

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Bibliographic Details
Main Authors: Atsushi Shibata, Hisao Shirohzu, Yusuke Iwakami, Tomoaki Abe, Chisato Emura, Eriko Aoki, Tadaaki Ohgi
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
RNA interference
chemically bridged siRNA
ESB RNA
strand bias
off-target effect
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000999

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http://www.sciencedirect.com/science/article/pii/S2162253123000999

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