Antigen Protease Activity on Intact or Tape-Stripped Skin Induces Acute Itch and T Helper Sensitization Leading to Airway Eosinophilia in Mice

Antigen Protease Activity on Intact or Tape-Stripped Skin Induces Acute Itch and T Helper Sensitization Leading to Airway Eosinophilia in Mice

Respiratory allergen sources such as house dust mites frequently contain proteases. In this study, we demonstrated that the epicutaneous application of a model protease antigen, papain, onto intact or tape-stripped ear skin of mice induced acute scratching behaviors and T helper (Th)2, Th9, Th17/Th2...

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Bibliographic Details
Main Authors: Toru Kimitsu, Seiji Kamijo, Tomoko Yoshimura, Yurie Masutani, Saya Shimizu, Keiko Takada, Punyada Suchiva, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda, Toshiro Takai
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:JID Innovations
Subjects:
Murine model
Protease antigen
Acute itch
Th sensitization
Atopic march
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026723000656

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http://www.sciencedirect.com/science/article/pii/S2667026723000656

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