The timing of HIV-1 infection of cells that persist on therapy is not strongly influenced by replication competency or cellular tropism of the provirus.

The timing of HIV-1 infection of cells that persist on therapy is not strongly influenced by replication competency or cellular tropism of the provirus.

People with HIV-1 (PWH) on antiretroviral therapy (ART) can maintain undetectable virus levels, but a small pool of infected cells persists. This pool is largely comprised of defective proviruses that may produce HIV-1 proteins but are incapable of making infectious virus, with only a fraction (~10%...

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Bibliografiske detaljer
Main Authors: Sarah B Joseph, Melissa-Rose Abrahams, Matthew Moeser, Lynn Tyers, Nancie M Archin, Olivia D Council, Amy Sondgeroth, Ean Spielvogel, Ann Emery, Shuntai Zhou, Deelan Doolabh, Sherazaan D Ismail, Salim Abdool Karim, David M Margolis, Sergei Kosakovsky Pond, Nigel Garrett, Ronald Swanstrom, Carolyn Williamson
Format: Article
Sprog:English
Udgivet: Public Library of Science (PLoS) 2024-02-01
Serier:PLoS Pathogens
Online adgang:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011974&type=printable

Internet

https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011974&type=printable

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