Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology

Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology

Abstract Tau deposits in astrocytes are frequently found in Alzheimer’s disease (AD) and other tauopathies. Since astrocytes do not express tau, the inclusions have been suggested to be of neuronal origin. However, the mechanisms behind their appearance and their relevance for disease progression re...

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Bibliographic Details
Main Authors: Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Martin Ingelsson, Jinar Rostami, Maria Lindskog, Anna Erlandsson
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Tau
Astrocytes
Neurons
Cell-to-cell spreading
hiPSCs
Online Access:https://doi.org/10.1186/s40478-023-01589-8

Internet

https://doi.org/10.1186/s40478-023-01589-8

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