Changes in DNA 5-Hydroxymethylcytosine Levels and the Underlying Mechanism in Non-functioning Pituitary Adenomas

Changes in DNA 5-Hydroxymethylcytosine Levels and the Underlying Mechanism in Non-functioning Pituitary Adenomas

Epigenetic factors have been proven to contribute to pituitary adenoma formation. 5-hydroxymethylcytosine (5hmC), which is catalyzed by ten-eleven translocation 2 (TET2), is related to DNA demethylation. In order to explore the pathogenesis of non-functioning pituitary adenomas (NFPAs), we detected...

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Bibliographic Details
Main Authors: Yiwen Xu, Yamei Niu, Kan Deng, Hui Pan, Feng Feng, Fengying Gong, Wei-Min Tong, Shi Chen, Lin Lu, Renzhi Wang, Hui You, Yong Yao, Huijuan Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Endocrinology
Subjects:
5hmC
NFPAs
TET2
ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS)
DNA demethylation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00361/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00361/full

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