NT-seq: a chemical-based sequencing method for genomic methylome profiling

Abstract DNA methylation plays vital roles in both prokaryotes and eukaryotes. There are three forms of DNA methylation in prokaryotes: N 6-methyladenine (6mA), N 4-methylcytosine (4mC), and 5-methylcytosine (5mC). Although many sequencing methods have been developed to sequence specific types of me...

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Bibliographic Details
Main Authors: Xuwen Li, Shiyuan Guo, Yan Cui, Zijian Zhang, Xinlong Luo, Margarita T. Angelova, Laura F. Landweber, Yinsheng Wang, Tao P. Wu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-022-02689-9