Estimating individualized treatment effects from randomized controlled trials: a simulation study to compare risk-based approaches

Estimating individualized treatment effects from randomized controlled trials: a simulation study to compare risk-based approaches

Abstract Background Baseline outcome risk can be an important determinant of absolute treatment benefit and has been used in guidelines for “personalizing” medical decisions. We compared easily applicable risk-based methods for optimal prediction of individualized treatment effects. Methods We simul...

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Bibliographic Details
Main Authors: Alexandros Rekkas, Peter R. Rijnbeek, David M. Kent, Ewout W. Steyerberg, David van Klaveren
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Medical Research Methodology
Subjects:
Treatment effect heterogeneity
Absolute benefit
Prediction models
Online Access:https://doi.org/10.1186/s12874-023-01889-6

Internet

https://doi.org/10.1186/s12874-023-01889-6

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