Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression

Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression

The 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) is a potential regulatory node in the mevalonate pathway that is frequently dysregulated in tumors. This study found that HMGCS1 expression is upregulated in stomach adenocarcinoma samples of patients and tumorspheres of gastric cancer cells. HM...

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Bibliographic Details
Main Authors: I-Han Wang, Tzu-Ting Huang, Ji-Lin Chen, Li-Wei Chu, Yueh-Hsin Ping, Kai-Wen Hsu, Kuo-Hung Huang, Wen-Liang Fang, Hsin-Chen Lee, Chian-Feng Chen, Chen-Chung Liao, Rong-Hong Hsieh, Tien-Shun Yeh
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
HMGCS1
mevalonate pathway
gastric cancer progression
integrated stress response
pluripotency
Online Access:https://www.mdpi.com/2072-6694/12/5/1088

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https://www.mdpi.com/2072-6694/12/5/1088

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