Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms

Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms

Abstract Background The endocannabinoid (eCB) system and the serotonin (5-HT) are both implicated in the severity of the depression. 5-HT is synthesized from the amino acid tryptophan (Trp), which is also a precursor for kynurenine (Kyn) whose production is increased at the expense of 5-HT in depres...

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Bibliographic Details
Main Authors: Stefano Comai, Nicolas Nunez, Tobias Atkin, Maykel F. Ghabrash, Rita Zakarian, Allan Fielding, Marie Saint-Laurent, Nancy Low, Garrett Sauber, Eugenio Ragazzi, Cecilia J. Hillard, Gabriella Gobbi
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Medicine
Subjects:
Depression
Endocannabinoids
Biomarkers
Serotonin
Kynurenine pathway
Online Access:https://doi.org/10.1186/s12916-024-03248-8

Internet

https://doi.org/10.1186/s12916-024-03248-8

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