CpG Frequency in the 5′ Third of the <italic toggle="yes">env</italic> Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

CpG Frequency in the 5′ Third of the <italic toggle="yes">env</italic> Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

ABSTRACT CpG dinucleotide suppression has been reported to allow HIV-1 to evade inhibition by the zinc-finger antiviral protein (ZAP). Here, we show that primate lentiviruses display marked differences in CpG frequencies across their genome, ranging from 0.44% in simian immunodeficiency virus SIVwrc...

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Bibliographic Details
Main Authors: Dorota Kmiec, Rayhane Nchioua, Scott Sherrill-Mix, Christina M. Stürzel, Elena Heusinger, Elisabeth Braun, Marcos V. P. Gondim, Dominik Hotter, Konstantin M. J. Sparrer, Beatrice H. Hahn, Daniel Sauter, Frank Kirchhoff
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
CpG dinucleotides
envelope gene
human immunodeficiency virus
restriction factors
zinc-finger antiviral protein
Online Access:https://journals.asm.org/doi/10.1128/mBio.02903-19

Internet

https://journals.asm.org/doi/10.1128/mBio.02903-19

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