A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2

A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2

During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of this developmental function is seen in human glioma, wherein Olig2...

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Bibliographic Details
Main Authors: Jing Zhou, An-Chi Tien, John A. Alberta, Scott B. Ficarro, Amelie Griveau, Yu Sun, Janhavee S. Deshpande, Joseph D. Card, Meghan Morgan-Smith, Wojciech Michowski, Rintaro Hashizume, C. David James, Keith L. Ligon, William D. Snider, Peter Sicinski, Jarrod A. Marto, David H. Rowitch, Charles D. Stiles
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
Olig2
phosphorylation
protein kinase
cyclin-dependent kinase
CDK
casein kinase 2
CK2
glycogen synthase kinase 3
GSK3
neural progenitor cells
NPCs
glioma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303200

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http://www.sciencedirect.com/science/article/pii/S2211124717303200

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