Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma

Abstract Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been under reported. To study the impact of intratumoral VHL heterogeneity observed in hum...

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Bibliographic Details
Main Authors: Junhui Hu, Ping Tan, Moe Ishihara, Nicholas A. Bayley, Shiruyeh Schokrpur, Jeremy G. Reynoso, Yangjun Zhang, Raymond J. Lim, Camelia Dumitras, Lu Yang, Steven M. Dubinett, Parmjit S. Jat, Jacques Van Snick, Jiaoti Huang, Arnold I. Chin, Robert M. Prins, Thomas G. Graeber, Hua Xu, Lily Wu
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01362-2

Internet

https://doi.org/10.1038/s41392-023-01362-2

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