A Spectroscopic Technique to Simultaneously Characterize Fatty Acid Uptake, Mitochondrial Activity, Vascularity, and Oxygen Saturation for Longitudinal Studies In Vivo

A Spectroscopic Technique to Simultaneously Characterize Fatty Acid Uptake, Mitochondrial Activity, Vascularity, and Oxygen Saturation for Longitudinal Studies In Vivo

Aggressive breast cancer has been shown to shift its metabolism towards increased lipid catabolism as the primary carbon source for oxidative phosphorylation. In this study, we present a technique to longitudinally monitor lipid metabolism and oxidative phosphorylation in pre-clinical tumor models t...

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Bibliographic Details
Main Authors: Riley J. Deutsch, Victoria W. D’Agostino, Enakshi D. Sunassee, Michelle Kwan, Megan C. Madonna, Gregory Palmer, Brian T. Crouch, Nimmi Ramanujam
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Metabolites
Subjects:
optical spectroscopy
tumor metabolism
fatty acid uptake
murine tumor lines
mitochondrial metabolism
tumor vascular environment
Online Access:https://www.mdpi.com/2218-1989/12/5/369

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https://www.mdpi.com/2218-1989/12/5/369

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