6-Valent Virus-Like Particle-Based Vaccine Induced Potent and Sustained Immunity Against Noroviruses in Mice

6-Valent Virus-Like Particle-Based Vaccine Induced Potent and Sustained Immunity Against Noroviruses in Mice

Norovirus is a major cause of acute gastroenteritis worldwide, and no vaccine is currently available. The genetic and antigenic diversity of Norovirus presents challenges for providing broad immune protection, which calls for a multivalent vaccine application. In this study, we investigated the poss...

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Bibliographic Details
Main Authors: Wenli Hou, Lihui Lv, Yihan Wang, Man Xing, Yingying Guo, Di Xie, Xin Wei, Xiuyue Zhang, Hui Liu, Jiling Ren, Dongming Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
6-valent norovirus vaccines
virus-like particles (VLPs)
dose-dependent tendency
humoral immune responses
T-cell responses
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.906275/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.906275/full

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