Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis

Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis

Peptidylarginine deiminases (PADIs) are strongly associated with the development of autoimmunity, neurodegeneration and cancer but their physiological roles are ill-defined. The nuclear deiminase PADI4 regulates pluripotency in the mammalian pre-implantation embryo but its function in tissue develop...

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Bibliographic Details
Main Authors: Christine Young, John R. Russell, Louie N. Van De Lagemaat, Hannah Lawson, Christopher Mapperley, Kamil R. Kranc, Maria A. Christophorou
Format: Article
Language:English
Published: The Company of Biologists 2022-06-01
Series:Biology Open
Subjects:
peptidylarginine deiminase iv (padi4)
haematopoietic development
bone marrow
differentiation
regeneration
ageing
Online Access:http://bio.biologists.org/content/11/6/bio059143

Internet

http://bio.biologists.org/content/11/6/bio059143

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