Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma

Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma

CD8+ T cells are crucial to establish antitumor immunity, and their high infiltration associates with favorable prognoses. However, several CD8+ T cell subpopulations in the tumor microenvironment may play different roles in prognosis, progression, and immunotherapy. Here, we analyzed prior publishe...

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Bibliographic Details
Main Authors: Weiwei Deng, Yubo Ma, Zhen Su, Yufang Liu, Panpan Liang, Chen Huang, Xiao Liu, Jin Shao, Yi Zhang, Kai Zhang, Jian Chen, Ruoyu Li
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
single-cell RNA-sequencing
melanoma
CD8+ T cell subpopulations
immune checkpoints
immunotherapy
bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301753

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http://www.sciencedirect.com/science/article/pii/S2372770520301753

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